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Abstract Delineation of geochemically distinct domains in Earth’s mantle is essential for understanding large-scale mantle convective flow and dynamics. Previous studies identify possible long-lived (>60 million-year) mantle isotopic domains (i.e. Antarctic-Zealandia, Pacific and Indian) near the Philippine Sea and western Pacific. Here we compile published basalt geochemistry of the Philippine Sea and surroundings and add new Mo isotopic and water content data for Gagua Ridge lavas, northwestern Philippine Sea, to distinguish slab-derived components during subduction. The water content, trace element, and Mo-Sr-Nd isotope compositions of Gagua Ridge arc lavas suggest that slab fluids and sediment melts are responsible for element recycling to the arc. The Philippine Sea basalts show both Indian and Zealandia-Antarctic Pb isotopic signatures; restoration of the basalt locations within a plate reconstruction shows the far-travelled Philippine Sea traversed these mantle domains. We establish the Indian mantle domain eastern boundary at ~120°E under SE Asia and the Indian Ocean. The Antarctic-Zealandia mantle domain lies south of ~10°N within the SW Pacific and has mostly remained in oceanic realms since ~400 Ma with only limited continental material input.